|Other Names||Max dimerization protein 1, Max dimerizer 1, Protein MAD, MXD1, MAD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.|
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MAX dimerization protein belongs to a subfamily ofMAX-interacting proteins. This protein competes with MYC forbinding to MAX to form a sequence-specific DNA-binding complex,acts as a transcriptional repressor (while MYC appears to functionas an activator) and is a candidate tumor suppressor. [provided byRefSeq].
Wu, S., et al. Exp. Cell Res. 315(18):3099-3111(2009)Chou, C.K., et al. Mol. Carcinog. 48(11):1048-1058(2009)Zhu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(18):6584-6589(2008)Jiang, K., et al. Nucleic Acids Res. 36(5):1517-1531(2008)Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
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