MXD1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q05195 |
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Clone Names | 100623129 |
Gene ID | 4084 |
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Other Names | Max dimerization protein 1, Max dimerizer 1, Protein MAD, MXD1, MAD |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MXD1 |
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Synonyms | MAD |
Function | Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAX dimerization protein belongs to a subfamily ofMAX-interacting proteins. This protein competes with MYC forbinding to MAX to form a sequence-specific DNA-binding complex,acts as a transcriptional repressor (while MYC appears to functionas an activator) and is a candidate tumor suppressor. [provided byRefSeq].
References
Wu, S., et al. Exp. Cell Res. 315(18):3099-3111(2009)Chou, C.K., et al. Mol. Carcinog. 48(11):1048-1058(2009)Zhu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(18):6584-6589(2008)Jiang, K., et al. Nucleic Acids Res. 36(5):1517-1531(2008)Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
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