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DOK5 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P104
Clone Names 100617083
Peptide ID 100617083
Additional Information
Gene ID 55816
Other Names Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK5
Synonyms C20orf180
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Tissue Location Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Research Areas
Citations (0)

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Background

The protein encoded by this gene is a member of the DOKfamily of membrane proteins, which are adapter proteins involved insignal transduction. The encoded protein interacts withphosphorylated receptor tyrosine kinases to mediate neuriteoutgrowth and activation of the MAP kinase pathway. In contrast toother DOK family proteins, this protein does not interact withRASGAP.

References

Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)Favre, C., et al. Genes Immun. 4(1):40-45(2003)

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$ 80.00
Cat# BP17160a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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