|Other Names||Docking protein 5, Downstream of tyrosine kinase 5, Insulin receptor substrate 6, IRS-6, IRS6, DOK5, C20orf180|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.|
|Tissue Location||Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the DOKfamily of membrane proteins, which are adapter proteins involved insignal transduction. The encoded protein interacts withphosphorylated receptor tyrosine kinases to mediate neuriteoutgrowth and activation of the MAP kinase pathway. In contrast toother DOK family proteins, this protein does not interact withRASGAP.
Liu, X., et al. J Am Acad Child Adolesc Psychiatry 49(1):33-41(2010)Tabassum, R., et al. BMC Med. Genet. 11, 35 (2010) :Shi, L., et al. Cell. Signal. 18(11):1995-2003(2006)Cai, D., et al. J. Biol. Chem. 278(28):25323-25330(2003)Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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