|Other Names||Ubiquitin-conjugating enzyme E2 G1, E217K, UBC7, Ubiquitin carrier protein G1, Ubiquitin-protein ligase G1, Ubiquitin-conjugating enzyme E2 G1, N-terminally processed, UBE2G1, UBE2G|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.|
|Tissue Location||Widely expressed, mainly in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family and catalyzes the covalentattachment of ubiquitin to other proteins. The protein may beinvolved in degradation of muscle-specific proteins. [provided byRefSeq].
Hassink, G., et al. Biochem. J. 388 (PT 2), 647-655 (2005) :Kim, B.W., et al. Mol. Endocrinol. 17(12):2603-2612(2003)Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)Imai, Y., et al. Cell 105(7):891-902(2001)Tiwari, S., et al. J. Biol. Chem. 276(19):16193-16200(2001)
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