|Other Names||Akirin-2, AKIRIN2, C6orf166|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).|
|Tissue Location||Widely expressed with the highest expression in peripheral blood leukocytes.|
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Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Komiya, Y., et al. J. Biol. Chem. 283(27):18753-18764(2008)Goto, A., et al. Nat. Immunol. 9(1):97-104(2008)Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :Vasan, R.S., et al. BMC Med. Genet. 8 SUPPL 1, S2 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)
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