|Other Names||Diphosphoinositol polyphosphate phosphohydrolase 2, DIPP-2, Diadenosine 5', 5'''-P1, P6-hexaphosphate hydrolase 2, 361-, Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4, NUDT4, DIPP2, KIAA0487|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.|
|Tissue Location||Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney|
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The protein encoded by this gene regulates the turnover ofdiphosphoinositol polyphosphates. The turnover of these high-energydiphosphoinositol polyphosphates represents a molecular switchingactivity with important regulatory consequences. Molecularswitching by diphosphoinositol polyphosphates may contribute toregulating intracellular trafficking. Several alternatively splicedtranscript variants have been described, but the full-length natureof some variants has not been determined. Isoforms DIPP2alpha andDIPP2beta are distinguishable from each other solely by DIPP2betapossessing one additional amino acid due to intron boundaryskidding in alternate splicing.
Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :Fisher, D.I., et al. J. Biol. Chem. 277(49):47313-47317(2002)Leslie, N.R., et al. BMC Biochem. 3, 20 (2002) :Caffrey, J.J., et al. Gene 269 (1-2), 53-60 (2001) :Caffrey, J.J., et al. J. Biol. Chem. 275(17):12730-12736(2000)
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