TNNI3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P19429 |
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Clone Names | 100427007 |
Gene ID | 7137 |
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Other Names | Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TNNI3 |
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Synonyms | TNNC1 |
Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Troponin I (TnI), along with troponin T (TnT) and troponinC (TnC), is one of 3 subunits that form the troponin complex of thethin filaments of striated muscle. TnI is the inhibitory subunit;blocking actin-myosin interactions and thereby mediating striatedmuscle relaxation. The TnI subfamily contains three genes:TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, andTnI-cardiac. This gene encodes the TnI-cardiac protein and isexclusively expressed in cardiac muscle tissues. Mutations in thisgene cause familial hypertrophic cardiomyopathy type 7 (CMH7) andfamilial restrictive cardiomyopathy (RCM).
References
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :Murakami, C., et al. Leg Med (Tokyo) 12(6):280-283(2010)Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)Di Chiara, A., et al. J Cardiovasc Med (Hagerstown) 11(8):587-592(2010)Napan, S., et al. Coron. Artery Dis. 21(5):261-265(2010)
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