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RTN1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16799 |
|---|---|
| Clone Names | 100427229 |
| Gene ID | 6252 |
|---|---|
| Other Names | Reticulon-1, Neuroendocrine-specific protein, RTN1, NSP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RTN1 |
|---|---|
| Synonyms | NSP |
| Function | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the family of reticulon encodinggenes. Reticulons are associated with the endoplasmic reticulum,and are involved in neuroendocrine secretion or in membranetrafficking in neuroendocrine cells. Alternatively splicedtranscript variants encoding different isoforms have beenidentified. Multiple promoters rather than alternative splicing ofinternal exons seem to be involved in this diversity. [provided byRefSeq].
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Fazi, B., et al. Oncogene 28(43):3814-3824(2009)Melino, S., et al. Biochemistry 48(2):242-253(2009)Di Sano, F., et al. J. Neurochem. 102(2):345-353(2007)Iwahashi, J., et al. Biochem. Biophys. Res. Commun. 355(2):508-512(2007)
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