|Other Names||Reticulon-1, Neuroendocrine-specific protein, RTN1, NSP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation|
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This gene belongs to the family of reticulon encodinggenes. Reticulons are associated with the endoplasmic reticulum,and are involved in neuroendocrine secretion or in membranetrafficking in neuroendocrine cells. Alternatively splicedtranscript variants encoding different isoforms have beenidentified. Multiple promoters rather than alternative splicing ofinternal exons seem to be involved in this diversity. [provided byRefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :Fazi, B., et al. Oncogene 28(43):3814-3824(2009)Melino, S., et al. Biochemistry 48(2):242-253(2009)Di Sano, F., et al. J. Neurochem. 102(2):345-353(2007)Iwahashi, J., et al. Biochem. Biophys. Res. Commun. 355(2):508-512(2007)
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