|Other Names||Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1, 6-mannosyltransferase, Asparagine-linked glycosylation protein 12 homolog, hALG12, Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1, 6-mannosyltransferase, Mannosyltransferase ALG12 homolog, Membrane protein SB87, ALG12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP- Man(7)GlcNAc(2)) required for protein glycosylation.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in fibroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the glycosyltransferase 22family. The encoded protein catalyzes the addition of the eighthmannose residue in an alpha-1,6 linkage onto thedolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2))required for protein glycosylation. Mutations in this gene havebeen associated with congenital disorder of glycosylation type Ig(CDG-Ig)characterized by abnormal N-glycosylation. [provided byRefSeq].
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Jaeken, J., et al. Curr. Opin. Pediatr. 16(4):434-439(2004)Jaeken, J. J. Inherit. Metab. Dis. 27(3):423-426(2004)Zdebska, E., et al. Pediatr. Res. 54(2):224-229(2003)Thiel, C., et al. Biochem. J. 367 (PT 1), 195-201 (2002) :
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