|Other Names||Dual specificity protein kinase TTK, Phosphotyrosine picked threonine-protein kinase, PYT, TTK, MPS1, MPS1L1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.|
|Tissue Location||Present in rapidly proliferating cell lines.|
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This gene encodes a dual specificity protein kinase withthe ability to phosphorylate tyrosine, serine and threonine.Associated with cell proliferation, this protein is essential forchromosome alignment at the centromere during mitosis and isrequired for centrosome duplication. It has been found to be acritical mitotic checkpoint protein for accurate segregation ofchromosomes during mitosis. Tumorigenesis may occur when thisprotein fails to degrade and produces excess centrosomes resultingin aberrant mitotic spindles. Alternative splicing results inmultiple transcript variants.
Cui, Y., et al. J. Biol. Chem. 285(43):32988-32998(2010)Maciejowski, J., et al. J. Cell Biol. 190(1):89-100(2010)Santaguida, S., et al. J. Cell Biol. 190(1):73-87(2010)Hewitt, L., et al. J. Cell Biol. 190(1):25-34(2010)Lan, W., et al. J. Cell Biol. 190(1):21-24(2010)
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