NVL Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O15381 |
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Other Accession | NP_996671.1, NP_002524.2 |
Clone Names | 110617010 |
Gene ID | 4931 |
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Other Names | Nuclear valosin-containing protein-like, NVLp, Nuclear VCP-like protein, NVL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NVL (HGNC:8070) |
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Function | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre- rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). |
Cellular Location | [Isoform 2]: Nucleus, nucleoplasm |
Tissue Location | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina |
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Provided below are standard protocols that you may find useful for product applications.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Nagahama, M., et al. Biochem. Biophys. Res. Commun. 346(3):1075-1082(2006)Nagahama, M., et al. Mol. Biol. Cell 15(12):5712-5723(2004)Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
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