|Other Names||Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could be a melanogenic enzyme.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines|
|Tissue Location||Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.|
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The protein encoded by this gene is a type I transmembraneglycoprotein which shows homology to the pMEL17 precursor, amelanocyte-specific protein. GPNMB shows expression in the lowlymetastatic human melanoma cell lines and xenografts but does notshow expression in the highly metastatic cell lines. GPNMB may beinvolved in growth delay and reduction of metastatic potential. Twotranscript variants encoding different isoforms have been found forthis gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Williams, M.D., et al. Melanoma Res. 20(3):184-190(2010)Hoashi, T., et al. FASEB J. 24(5):1616-1629(2010)Rose, A.A., et al. Clin. Cancer Res. 16(7):2147-2156(2010)Rose, A.A., et al. PLoS ONE 5 (8), E12093 (2010) :
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