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GPNMB Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14956
Clone Names 100623204
Peptide ID 100623204
Additional Information
Gene ID 10457
Other Names Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HGFIN, NMB
Function Could be a melanogenic enzyme.
Cellular Location Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines
Tissue Location Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain.
Research Areas
Citations (0)

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The protein encoded by this gene is a type I transmembraneglycoprotein which shows homology to the pMEL17 precursor, amelanocyte-specific protein. GPNMB shows expression in the lowlymetastatic human melanoma cell lines and xenografts but does notshow expression in the highly metastatic cell lines. GPNMB may beinvolved in growth delay and reduction of metastatic potential. Twotranscript variants encoding different isoforms have been found forthis gene.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Williams, M.D., et al. Melanoma Res. 20(3):184-190(2010)Hoashi, T., et al. FASEB J. 24(5):1616-1629(2010)Rose, A.A., et al. Clin. Cancer Res. 16(7):2147-2156(2010)Rose, A.A., et al. PLoS ONE 5 (8), E12093 (2010) :

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$ 80.00
Cat# BP17232b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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