|Other Names||Protein OS-9, Amplified in osteosarcoma 9, OS9|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines Isoform 2 is the major isoform detected in all cell types examined|
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This gene encodes a protein that is highly expressed inosteosarcomas. This protein binds to the hypoxia-inducible factor 1(HIF-1), a key regulator of the hypoxic response and angiogenesis,and promotes the degradation of one of its subunits. Alternatetranscriptional splice variants, encoding different isoforms, havebeen characterized.
Feng, T., et al. Hum. Genet. 128(3):269-280(2010)Mikami, K., et al. Glycobiology 20(3):310-321(2010)Hosokawa, N., et al. J. Biol. Chem. 284(25):17061-17068(2009)Jansen, B.J., et al. Mol. Immunol. 46(4):505-515(2009)Alcock, F., et al. J. Mol. Biol. 385(4):1032-1042(2009)
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