|Other Names||Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Lipid- anchor|
|Tissue Location||Expressed in peripheral blood monocytes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Belongs to the GBP family.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wehner, M., et al. FEBS J. 277(7):1597-1605(2010)Ito, Y., et al. J. Infect. Dis. 197(5):663-666(2008)Tripal, P., et al. J. Interferon Cytokine Res. 27(1):44-52(2007)Fellenberg, F., et al. J. Invest. Dermatol. 122(6):1510-1517(2004)
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