|Other Names||Guanylate-binding protein 5, GBP-TA antigen, GTP-binding protein 5, GBP-5, Guanine nucleotide-binding protein 5, GBP5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Lipid- anchor|
|Tissue Location||Expressed in peripheral blood monocytes (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Belongs to the GBP family.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Wehner, M., et al. FEBS J. 277(7):1597-1605(2010)Ito, Y., et al. J. Infect. Dis. 197(5):663-666(2008)Tripal, P., et al. J. Interferon Cytokine Res. 27(1):44-52(2007)Fellenberg, F., et al. J. Invest. Dermatol. 122(6):1510-1517(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.