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PIGO Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TEQ8 |
|---|---|
| Clone Names | 110726161 |
| Gene ID | 84720 |
|---|---|
| Other Names | GPI ethanolamine phosphate transferase 3, 2---, Phosphatidylinositol-glycan biosynthesis class O protein, PIG-O, PIGO |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIGO |
|---|---|
| Function | Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI- anchor to the C-terminus of the proteins by an amide bond. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JJI6}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is involved inglycosylphosphatidylinositol (GPI)-anchor biosynthesis. TheGPI-anchor is a glycolipid which contains three mannose moleculesin its core backbone. The GPI-anchor is found on many blood cellsand serves to anchor proteins to the cell surface. This protein isinvolved in the transfer of ethanolaminephosphate (EtNP) to thethird mannose in GPI. At least two alternatively splicedtranscripts encoding distinct isoforms have been found for thisgene.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Humphray, S.J., et al. Nature 429(6990):369-374(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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