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SLC5A2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P31639 |
|---|---|
| Clone Names | 100603165 |
| Gene ID | 6524 |
|---|---|
| Other Names | Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2, SLC5A2, SGLT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC5A2 {ECO:0000303|PubMed:14614622} |
|---|---|
| Function | Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q923I7}; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sodium glucosecotransporter family which are sodium-dependent glucose transportproteins. The encoded protein is the major cotransporter involvedin glucose reabsorption in the kidney. Mutations in this gene areassociated with renal glucosuria.
References
Calado, J., et al. Nephrol. Dial. Transplant. 23(12):3874-3879(2008)Castaneda, F., et al. Int J Med Sci 4(3):131-139(2007)Magen, D., et al. Kidney Int. 67(1):34-41(2005)Calado, J., et al. Hum. Genet. 114(3):314-316(2004)Santer, R., et al. J. Am. Soc. Nephrol. 14(11):2873-2882(2003)
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