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Synthetic peptide
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- BACKGROUND
| Primary Accession | Q86T65 |
|---|---|
| Clone Names | 100617145 |
| Peptide ID | 100617145 |
| Gene ID | 23500 |
|---|---|
| Other Names | Disheveled-associated activator of morphogenesis 2, DAAM2, KIAA0381 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DAAM2 (HGNC:18143) |
|---|---|
| Function | Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway. Acts downstream of PITX2 in the developing gut and is required for left/right asymmetry within dorsal mesentery: affects mesenchymal condensation by lengthening cadherin-based junctions through WNT5A and non-canonical Wnt signaling, inducing polarized condensation in the left dorsal mesentery necessary to initiate gut rotation. Together with DAAM1, required for myocardial maturation and sarcomere assembly. |
| Tissue Location | Expressed in most tissues examined. |
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Background
DAAM2, dishevelled associated activator of morphogenesis 2, belongs to the formin homology family and contains a DAD (diaphanous autoregulatory) domain, an FH1 (formin homology 1) domain, an FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding/ formin homology 3) domain. It is a recently identified planar cell polarity (PCP) signaling molecule implicated in the regulation of cellular polarity, convergent extension, and invasion. It is suggested that DAAM2 is closely related to DAAM1 and hence along with DAAM1 it may also be required in Wnt/Fz signaling and activation of Rho and in regulating cytoskeleton architecture. It is expressed in most tissues examined.
References
Repapi, E., et al. Nat. Genet. 42(1):36-44(2010)Hirata, H., et al. Cancer 115(19):4488-4503(2009)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Katoh, M., et al. Int. J. Oncol. 22(4):915-920(2003)Habas, R., et al. Cell 107(7):843-854(2001)
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