|Other Names||Disheveled-associated activator of morphogenesis 2, DAAM2, KIAA0381|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in most tissues examined.|
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DAAM2, dishevelled associated activator of morphogenesis 2, belongs to the formin homology family and contains a DAD (diaphanous autoregulatory) domain, an FH1 (formin homology 1) domain, an FH2 (formin homology 2) domain and a GBD/FH3 (Rho GTPase-binding/ formin homology 3) domain. It is a recently identified planar cell polarity (PCP) signaling molecule implicated in the regulation of cellular polarity, convergent extension, and invasion. It is suggested that DAAM2 is closely related to DAAM1 and hence along with DAAM1 it may also be required in Wnt/Fz signaling and activation of Rho and in regulating cytoskeleton architecture. It is expressed in most tissues examined.
Repapi, E., et al. Nat. Genet. 42(1):36-44(2010)Hirata, H., et al. Cancer 115(19):4488-4503(2009)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Katoh, M., et al. Int. J. Oncol. 22(4):915-920(2003)Habas, R., et al. Cell 107(7):843-854(2001)
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