|Other Names||Collagen alpha-6(IV) chain, COL4A6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|
|Cellular Location||Secreted, extracellular space, extracellular matrix, basement membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of the six subunits of type IVcollagen, the major structural component of basement membranes.Like the other members of the type IV collagen gene family, thisgene is organized in a head-to-head conformation with another typeIV collagen gene, alpha 5 type IV collagen, so that the gene pairshares a common promoter. Deletions in the alpha 5 gene that extendinto the alpha 6 gene result in diffuse leiomyomatosis accompanyingthe X-linked Alport syndrome caused by the deletion in the alpha 5gene. Two splice variants have been identified for this gene.
Romero, R., et al. Am. J. Obstet. Gynecol. (2010) In press :Bailey, S.D., et al. Diabetes Care (2010) In press :Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Skovbjerg, H., et al. BMC Cancer 9, 136 (2009) :
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