RBM23 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86U06 |
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Clone Names | 110617129 |
Gene ID | 55147 |
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Other Names | Probable RNA-binding protein 23, RNA-binding motif protein 23, RNA-binding region-containing protein 4, Splicing factor SF2, RBM23, RNPC4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RBM23 {ECO:0000303|PubMed:31693891, ECO:0000312|HGNC:HGNC:20155} |
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Function | RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343). |
Cellular Location | Nucleus. |
Tissue Location | Highly expressed in placenta, liver, skeletal muscle, heart and kidney (PubMed:15694343). Expressed at lower levels in the colon, thymus, spleen, small intestine and lung (PubMed:15694343). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the U2AF-like family of RNAbinding proteins. This protein interacts with some steroid nuclearreceptors, localizes to the promoter of a steroid- responsive gene,and increases transcription of steroid-responsive transcriptionalreporters in a hormone-dependent manner. It is also implicated inthe steroid receptor-dependent regulation of alternative splicing.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Stelzl, U., et al. Cell 122(6):957-968(2005)Dowhan, D.H., et al. Mol. Cell 17(3):429-439(2005)
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