|Other Names||UPF0568 protein C14orf166, CLE7 homolog, CLE, C14orf166|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA- splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264).|
|Tissue Location||Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney Overexpressed in many brain tumors.|
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Belongs to the UPF0568 family.
Cui, Y., et al. Int. J. Cancer 124(7):1614-1621(2009)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Howng, S.L., et al. FEBS Lett. 566 (1-3), 162-168 (2004) :Huarte, M., et al. J. Virol. 75(18):8597-8604(2001)Dawson, S.J., et al. J. Infect. 24(3):317-320(1992)
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