|Other Names||Acidic leucine-rich nuclear phosphoprotein 32 family member C, Phosphoprotein 32-related protein 1, Tumorigenic protein pp32r1, ANP32C, PP32R1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue|
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Phosphoprotein 32 (PP32) is a tumor suppressor that caninhibit several types of cancers, including prostate and breastcancers. The protein encoded by this gene is one of at least twoproteins that are similar in amino acid sequence to PP32 and arepart of the same acidic nuclear phosphoprotein gene family.However, unlike PP32, the encoded protein is tumorigenic. The tumorsuppressor function of PP32 has been localized to a 25 amino acidregion that is divergent between PP32 and the protein encoded bythis gene. This gene does not contain introns. [provided byRefSeq].
Matilla, A., et al. Cerebellum 4(1):7-18(2005)Kochevar, G.J., et al. Hum. Mutat. 23(6):546-551(2004)Fan, Z., et al. Nat. Immunol. 4(2):145-153(2003)Kadkol, S.S., et al. Breast Cancer Res. Treat. 68(1):65-73(2001)Kadkol, S.S., et al. Nat. Med. 5 (9), 1087 (1999) :
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