|Other Names||Calcium-binding protein 4, CaBP4, CABP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).|
|Cellular Location||Cytoplasm. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors.|
|Tissue Location||Expressed in retina and in the inner hair cells (IHC) of the cochlea|
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This gene encodes a member of the CABP family of calciumbinding protein characterized by four EF-hand motifs. Mutations inthis gene are associated with congenital stationary night blindnesstype 2B.
Aldahmesh, M.A., et al. Mol. Vis. 16, 207-212 (2010) :Littink, K.W., et al. Invest. Ophthalmol. Vis. Sci. 50(5):2344-2350(2009)Zeitz, C., et al. Am. J. Hum. Genet. 79(4):657-667(2006)Taylor, T.D., et al. Nature 440(7083):497-500(2006)Haeseleer, F., et al. Nat. Neurosci. 7(10):1079-1087(2004)
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