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NPLOC4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TAT6 |
|---|---|
| Clone Names | 110717130 |
| Gene ID | 55666 |
|---|---|
| Other Names | Nuclear protein localization protein 4 homolog, Protein NPL4, NPLOC4, KIAA1499, NPL4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NPLOC4 |
|---|---|
| Synonyms | KIAA1499, NPL4 |
| Function | The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54} Note=Associated with the endoplasmic reticulum and nuclear {ECO:0000250|UniProtKB:Q9ES54} |
| Tissue Location | Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).
References
Liu, F., et al. PLoS Genet. 6, E1000934 (2010) :Lass, A., et al. Exp. Cell Res. 314(14):2715-2723(2008)McConnell, E., et al. Biochem. Biophys. Res. Commun. 355(4):1087-1090(2007)Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)Botta, A., et al. Gene 275(1):39-46(2001)
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