|Other Names||Zinc finger protein 322, Zinc finger protein 322A, Zinc finger protein 388, Zinc finger protein 489, ZNF322, ZNF322A, ZNF388, ZNF489|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ZNF322A, ZNF388, ZNF489|
|Function||Transcriptional activator (PubMed:15555580). Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG proximal promoter, and enhances expression of both genes (By similarity). Can also bind to numerous other gene promoters and regulates expression of many other pluripotency factors, either directly or indirectly (By similarity). Promotes inhibition of MAPK signaling during embryonic stem cell differentiation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly found in the nucleus.|
|Tissue Location||Ubiquitous. Highly expressed in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
ZNF322A is a member of the zinc-finger transcriptionfactor family and may regulate transcriptional activation in MAPK(see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed15555580]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :Li, Y., et al. Biochem. Biophys. Res. Commun. 325(4):1383-1392(2004)
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