|Other Names||Cytochrome c oxidase subunit 5B, mitochondrial, Cytochrome c oxidase polypeptide Vb, COX5B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome C oxidase (COX) is the terminal enzyme of themitochondrial respiratory chain. It is a multi-subunit enzymecomplex that couples the transfer of electrons from cytochrome c tomolecular oxygen and contributes to a proton electrochemicalgradient across the inner mitochondrial membrane. The complexconsists of 13 mitochondrial- and nuclear-encoded subunits. Themitochondrially-encoded subunits perform the electron transfer andproton pumping activities. The functions of the nuclear-encodedsubunits are unknown but they may play a role in the regulation andassembly of the complex. This gene encodes the nuclear-encodedsubunit Vb of the human mitochondrial respiratory chain enzyme.
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)Chen, Z.X., et al. Cell Death Differ. 17(3):408-420(2010)Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)Beauchemin, A.M., et al. Brain Res. Bull. 56 (3-4), 285-297 (2001) :Wu, H., et al. J. Biol. Chem. 275(42):32491-32498(2000)
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