|Other Names||PRA1 family protein 3, ADP-ribosylation factor-like protein 6-interacting protein 5, ARL-6-interacting protein 5, Aip-5, Cytoskeleton-related vitamin A-responsive protein, Dermal papilla-derived protein 11, GTRAP3-18, Glutamate transporter EAAC1-interacting protein, JM5, Prenylated Rab acceptor protein 2, Protein JWa, Putative MAPK-activating protein PM27, ARL6IP5, DERP11, JWA, PRA2, PRAF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DERP11, JWA, PRA2, PRAF3|
|Function||Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Cytoplasm. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity)|
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Provided below are standard protocols that you may find useful for product applications.
Expression of this gene is affected by vitamin A. Theencoded protein of this gene may be associated with thecytoskeleton. A similar protein in rats may play a role in theregulation of cell differentiation. The rat protein binds andinhibits the cell membrane glutamate transporter EAAC1. Theexpression of the rat gene is upregulated by retinoic acid, whichresults in a specific reduction in EAAC1-mediated glutamatetransport.
Edenberg, H.J., et al. Alcohol. Clin. Exp. Res. 34(5):840-852(2010)Akiduki, S., et al. J. Biol. Chem. 283(46):31323-31332(2008)Ruggiero, A.M., et al. J. Biol. Chem. 283(10):6175-6183(2008)Watabe, M., et al. Mol. Pharmacol. 72(5):1103-1110(2007)Zhu, Y.J., et al. J. Toxicol. Environ. Health Part A 70(11):895-900(2007)
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