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SPRY2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O43597 |
|---|---|
| Clone Names | 100507232 |
| Gene ID | 10253 |
|---|---|
| Other Names | Protein sprouty homolog 2, Spry-2, SPRY2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SPRY2 |
|---|---|
| Function | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB- induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (PubMed:17974561). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein belonging to the sproutyfamily. The encoded protein contains a carboxyl-terminalcysteine-rich domain essential for the inhibitory activity onreceptor tyrosine kinase signaling proteins and is required forgrowth factor stimulated translocation of the protein to membraneruffles. In primary dermal endothelial cells this gene istransiently upregulated in response to fibroblast growth factortwo. This protein is indirectly involved in the non-cell autonomousinhibitory effect on fibroblast growth factor two signaling. Theprotein interacts with Cas-Br-M (murine) ectropic retroviraltransforming sequence, and can function as a bimodal regulator ofepidermal growth factor receptor/mitogen-activated protein kinasesignaling. This protein may play a role in alveoli branching duringlung development as shown by a similar mouse protein. [provided byRefSeq].
References
Ma, Y., et al. Cancer Lett. 298(2):150-158(2010)Holgren, C., et al. Oncogene 29(38):5241-5253(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Chitra, E., et al. Retrovirology 7, 62 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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