|Other Names||Protein sprouty homolog 2, Spry-2, SPRY2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)|
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This gene encodes a protein belonging to the sproutyfamily. The encoded protein contains a carboxyl-terminalcysteine-rich domain essential for the inhibitory activity onreceptor tyrosine kinase signaling proteins and is required forgrowth factor stimulated translocation of the protein to membraneruffles. In primary dermal endothelial cells this gene istransiently upregulated in response to fibroblast growth factortwo. This protein is indirectly involved in the non-cell autonomousinhibitory effect on fibroblast growth factor two signaling. Theprotein interacts with Cas-Br-M (murine) ectropic retroviraltransforming sequence, and can function as a bimodal regulator ofepidermal growth factor receptor/mitogen-activated protein kinasesignaling. This protein may play a role in alveoli branching duringlung development as shown by a similar mouse protein. [provided byRefSeq].
Ma, Y., et al. Cancer Lett. 298(2):150-158(2010)Holgren, C., et al. Oncogene 29(38):5241-5253(2010)Jagomagi, T., et al. Eur. J. Oral Sci. 118(3):213-220(2010)Chitra, E., et al. Retrovirology 7, 62 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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