|Other Names||DNA helicase MCM8, Minichromosome maintenance 8, MCM8, C20orf154|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.|
|Cellular Location||Nucleus. Note=Localizes to nuclear foci and colocalizes with RAD51|
|Tissue Location||Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers|
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The protein encoded by this gene is one of the highlyconserved mini-chromosome maintenance proteins (MCM) that areessential for the initiation of eukaryotic genome replication. Thehexameric protein complex formed by the MCM proteins is a keycomponent of the pre-replication complex (pre_RC) and may beinvolved in the formation of replication forks and in therecruitment of other DNA replication related proteins. This proteincontains the central domain that is conserved among the MCMproteins. This protein has been shown to co-immunoprecipitate withMCM4, 6 and 7, which suggests that it may interact with other MCMproteins and play a role in DNA replication. Alternatively splicedtranscript variants encoding distinct isoforms have been described.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)He, C., et al. Nat. Genet. 41(6):724-728(2009)Stolk, L., et al. Nat. Genet. 41(6):645-647(2009)
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