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LY96 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y6Y9 |
|---|---|
| Clone Names | 100517298 |
| Gene ID | 23643 |
|---|---|
| Other Names | Lymphocyte antigen 96, Ly-96, ESOP-1, Protein MD-2, LY96, ESOP1, MD2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LY96 |
|---|---|
| Synonyms | ESOP1, MD2 |
| Function | Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). |
| Cellular Location | Secreted, extracellular space. Secreted Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein which associates withtoll-like receptor 4 on the cell surface and confers responsivenessto lipopolysaccyaride (LPS), thus providing a link between thereceptor and LPS signaling. Studies of the mouse ortholog suggestthat this gene may be involved in endotoxin neutralization.Alternative splicing results in multiple transcript variantsencoding different isoforms.
References
Meng, J., et al. J. Biol. Chem. 285(36):27935-27943(2010)Gray, P., et al. J. Immunol. 184(11):6359-6366(2010)Salvesen, B., et al. Mol. Immunol. 47(6):1226-1234(2010)Ohnishi, T., et al. Microbiol. Immunol. 54(2):74-80(2010)Xue, Y., et al. Genet. Mol. Res. 9(3):1584-1590(2010)
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