|Other Names||Lymphocyte antigen 96, Ly-96, ESOP-1, Protein MD-2, LY96, ESOP1, MD2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram- positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).|
|Cellular Location||Secreted, extracellular space. Secreted. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which associates withtoll-like receptor 4 on the cell surface and confers responsivenessto lipopolysaccyaride (LPS), thus providing a link between thereceptor and LPS signaling. Studies of the mouse ortholog suggestthat this gene may be involved in endotoxin neutralization.Alternative splicing results in multiple transcript variantsencoding different isoforms.
Meng, J., et al. J. Biol. Chem. 285(36):27935-27943(2010)Gray, P., et al. J. Immunol. 184(11):6359-6366(2010)Salvesen, B., et al. Mol. Immunol. 47(6):1226-1234(2010)Ohnishi, T., et al. Microbiol. Immunol. 54(2):74-80(2010)Xue, Y., et al. Genet. Mol. Res. 9(3):1584-1590(2010)
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