|Other Names||A-kinase anchor protein 8-like, AKAP8-like protein, Helicase A-binding protein 95, HAP95, Homologous to AKAP95 protein, HA95, Neighbor of A-kinase-anchoring protein 95, Neighbor of AKAP95, AKAP8L, NAKAP, NAKAP95|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.|
|Cellular Location||Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm Associated with the nuclear matrix.|
|Tissue Location||Expressed in the brain cortex (at protein level).|
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AKAP8L could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.
Sugiura, T., et al. Exp. Cell Res. 314(7):1519-1528(2008)Kvissel, A.K., et al. Exp. Cell Res. 313(13):2795-2809(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Sayer, J.A., et al. Neuromolecular Med. 7(4):297-310(2005)
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