|Other Names||1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-4, hPLCD4, Phosphoinositide phospholipase C-delta-4, Phospholipase C-delta-4, PLC-delta-4, PLCD4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.|
|Cellular Location||Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum|
|Tissue Location||Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylinositol-specific phospholipase C (PLC) playsan important role in receptor-mediated signal transduction bygenerating 2 second messenger molecules, inositol1,4,5-triphosphate (IP3) and diacylglycerol, fromphosphatidylinositol 4,5-bisphosphate (PIP2). PLC comprises adiverse family of enzymes that differ in structure and tissuedistribution (Berridge, 1993 [PubMed 8381210]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Chae, S.W., et al. Mol. Biol. Rep. 34(2):69-77(2007)
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