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PLCD4 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BRC7
Clone Names 100712069
Peptide ID 100712069
Additional Information
Gene ID 84812
Other Names 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-4, hPLCD4, Phosphoinositide phospholipase C-delta-4, Phospholipase C-delta-4, PLC-delta-4, PLCD4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLCD4
Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Cellular Location Membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Endoplasmic reticulum. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum
Tissue Location Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
Research Areas
Citations (0)

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Phosphatidylinositol-specific phospholipase C (PLC) playsan important role in receptor-mediated signal transduction bygenerating 2 second messenger molecules, inositol1,4,5-triphosphate (IP3) and diacylglycerol, fromphosphatidylinositol 4,5-bisphosphate (PIP2). PLC comprises adiverse family of enzymes that differ in structure and tissuedistribution (Berridge, 1993 [PubMed 8381210]).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Segat, L., et al. Vaccine 28(10):2201-2206(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :Chae, S.W., et al. Mol. Biol. Rep. 34(2):69-77(2007)

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$ 80.00
Cat# BP17424b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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