|Other Names||Chloride channel protein ClC-Ka, Chloride channel Ka, ClC-K1, CLCNKA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins|
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This gene is a member of the CLC family of voltage-gatedchloride channels. The encoded protein is predicted to have 12transmembrane domains, and requires a beta subunit called barttinto form a functional channel. It is thought to function in saltreabsorption in the kidney and potassium recycling in the innerear. The gene is highly similar to CLCNKB, which is located 10 kbdownstream from this gene. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Kramer, B.K., et al. Nat Clin Pract Nephrol 4(1):38-46(2008)Martinez, G.Q., et al. PLoS ONE 3 (7), E2746 (2008) :Sile, S., et al. Hum. Hered. 65(1):33-46(2008)
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