|Other Names||Ribosomal protein S6 kinase alpha-2, S6K-alpha-2, 90 kDa ribosomal protein S6 kinase 2, p90-RSK 2, p90RSK2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, MAPKAP kinase 1c, MAPKAPK-1c, Protein-tyrosine kinase Mpk-9, Ribosomal S6 kinase 3, RSK-3, pp90RSK3, Rps6ka2, Mapkapk1c, Rsk3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
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Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB (By similarity).
Bae, G.U., et al. Mol. Biol. Cell 20(23):4920-4931(2009)Fischer, M., et al. Mol. Cell. Neurosci. 42(2):134-141(2009)Cho, Y.Y., et al. Cancer Res. 67(17):8104-8112(2007)Panasyuk, G., et al. J. Biol. Chem. 281(42):31188-31201(2006)Maekawa, N., et al. Circulation 113(21):2516-2523(2006)
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