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Mouse Ripk1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q60855
Clone Names 110328060
Peptide ID 110328060
Additional Information
Gene ID 19766
Other Names Receptor-interacting serine/threonine-protein kinase 1, Cell death protein RIP, Receptor-interacting protein 1, RIP-1, Serine/threonine-protein kinase RIP, Ripk1, Rinp, Rip
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ripk1
Synonyms Rinp, Rip
Function Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).
Cellular Location Cytoplasm. Cell membrane.
Tissue Location Found at low levels in all tissues.
Research Areas
Citations (0)

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Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.


Wong, W.W., et al. Cell Death Differ. 17(3):482-487(2010)Kamarajan, P., et al. Mol. Biol. Cell 21(3):481-488(2010)Xu, G., et al. J. Biol. Chem. 285(2):969-978(2010)Haas, T.L., et al. Mol. Cell 36(5):831-844(2009)Chang, M., et al. Nat. Immunol. 10(10):1089-1095(2009)

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$ 80.00
Cat# BP17439c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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