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LETM1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95202 |
|---|---|
| Clone Names | 110617030 |
| Gene ID | 3954 |
|---|---|
| Other Names | LETM1 and EF-hand domain-containing protein 1, mitochondrial, Leucine zipper-EF-hand-containing transmembrane protein 1, LETM1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LETM1 (HGNC:6556) |
|---|---|
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24898248, PubMed:24344246, PubMed:29123128, PubMed:32139798, PubMed:36321428, PubMed:36055214). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128). Functions also as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that is localized to the innermitochondrial membrane. The protein functions to maintain themitochondrial tubular shapes and is required for normalmitochondrial morphology and cellular viability. Mutations in thisgene cause Wolf-Hirschhorn syndrome, a complex malformationsyndrome caused by the deletion of parts of the distal short arm ofchromosome 4. Related pseudogenes have been identified onchromosomes 8, 15 and 19.
References
Jiang, D., et al. Science 326(5949):144-147(2009)Piao, L., et al. Cell. Signal. 21(5):767-777(2009)Piao, L., et al. Cancer Res. 69(8):3397-3404(2009)Tamai, S., et al. J. Cell. Sci. 121 (PT 15), 2588-2600 (2008) :Dimmer, K.S., et al. Hum. Mol. Genet. 17(2):201-214(2008)
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