|Other Names||LETM1 and EF-hand domain-containing protein 1, mitochondrial, Leucine zipper-EF-hand-containing transmembrane protein 1, LETM1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).|
|Cellular Location||Mitochondrion inner membrane; Single- pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is localized to the innermitochondrial membrane. The protein functions to maintain themitochondrial tubular shapes and is required for normalmitochondrial morphology and cellular viability. Mutations in thisgene cause Wolf-Hirschhorn syndrome, a complex malformationsyndrome caused by the deletion of parts of the distal short arm ofchromosome 4. Related pseudogenes have been identified onchromosomes 8, 15 and 19.
Jiang, D., et al. Science 326(5949):144-147(2009)Piao, L., et al. Cell. Signal. 21(5):767-777(2009)Piao, L., et al. Cancer Res. 69(8):3397-3404(2009)Tamai, S., et al. J. Cell. Sci. 121 (PT 15), 2588-2600 (2008) :Dimmer, K.S., et al. Hum. Mol. Genet. 17(2):201-214(2008)
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