|Other Names||Liprin-beta-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1, PTPRF-interacting protein-binding protein 1, hSGT2, PPFIBP1, KIAA1230|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.|
|Tissue Location||Widely expressed. Absent in liver.|
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The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. It has been proposedthat liprins are multivalent proteins that form complex structuresand act as scaffolds for the recruitment and anchoring of LARfamily of tyrosine phosphatases. This protein was found to interactwith S100A4, a calcium-binding protein related to tumorinvasiveness and metastasis. In vitro experiment demonstrated thatthe interaction inhibited the phosphorylation of this protein byprotein kinase C and protein kinase CK2. Alternatively splicedtranscript variants encoding distinct isoforms have been reported.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Norrmen, C., et al. Blood 115(4):906-909(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
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