|Other Names||DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF|
|Tissue Location||High levels in brain, heart, kidney and skeletal muscle.|
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Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Chial, H.J., et al. PLoS ONE 5 (8), E12471 (2010) :Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)Chial, H.J., et al. Traffic 9(2):215-229(2008)Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :Mao, X., et al. Nat. Cell Biol. 8(5):516-523(2006)
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