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MTMR14 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NCE2 |
|---|---|
| Clone Names | 110726131 |
| Gene ID | 64419 |
|---|---|
| Other Names | Myotubularin-related protein 14, 313-, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, NS5ATP4ABP1, hJumpy, MTMR14, C3orf29 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MTMR14 |
|---|---|
| Synonyms | C3orf29 |
| Function | Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. |
| Cellular Location | Cytoplasm. Note=Found in reticular structures and plasma membrane ruffles Concentrated near the nucleus |
| Tissue Location | Expressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a myotubularin-related protein. Theencoded protein is a phosphoinositide phosphatase that specificallydephosphorylates phosphatidylinositol 3,5-biphosphate andphosphatidylinositol 3-phosphate. Mutations in this gene arecorrelated with autosomal dominant centronuclear myopathy.Alternate splicing results in multiple transcript variants. Apseudogene of this gene is found on chromosome 18.
References
Gibbs, E.M., et al. Autophagy 6(6):819-820(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Vergne, I., et al. EMBO J. 28(15):2244-2258(2009)Tosch, V., et al. Hum. Mol. Genet. 15(21):3098-3106(2006)
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