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MTRF1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75570 |
|---|---|
| Clone Names | 110726132 |
| Gene ID | 9617 |
|---|---|
| Other Names | Peptide chain release factor 1, mitochondrial, MRF-1, MtRF-1, MTRF1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RF1M |
|---|---|
| Function | Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non- canonical stop codons AGG and AGA (PubMed:36302763, PubMed:36596788, PubMed:37141370). Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively (PubMed:37141370). Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA (PubMed:37141370). |
| Cellular Location | Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene was determined by insilico methods to be a mitochondrial protein with similarity to thepeptide chain release factors (RFs) discovered in bacteria andyeast. The peptide chain release factors direct the termination oftranslation in response to the peptide chain termination codons.Initially thought to have a role in the termination of mitochondriaprotein synthesis, a recent publication found no mitochondrialtranslation release functionality. Multiple alternatively splicedtranscript variants have been suggested by mRNA and EST data;however, their full-length natures are not clear. [provided byRefSeq].
References
Antonicka, H., et al. Am. J. Hum. Genet. 87(1):115-122(2010)Nozaki, Y., et al. Genes Cells 13(5):429-438(2008)Soleimanpour-Lichaei, H.R., et al. Mol. Cell 27(5):745-757(2007)Hansen, L.L., et al. Cytogenet. Cell Genet. 88 (1-2), 91-92 (2000) :Zhang, Y., et al. Biochim. Biophys. Acta 1443 (1-2), 245-250 (1998) :
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