|Other Names||Peptide chain release factor 1, mitochondrial, MRF-1, MtRF-1, MTRF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA.|
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The protein encoded by this gene was determined by insilico methods to be a mitochondrial protein with similarity to thepeptide chain release factors (RFs) discovered in bacteria andyeast. The peptide chain release factors direct the termination oftranslation in response to the peptide chain termination codons.Initially thought to have a role in the termination of mitochondriaprotein synthesis, a recent publication found no mitochondrialtranslation release functionality. Multiple alternatively splicedtranscript variants have been suggested by mRNA and EST data;however, their full-length natures are not clear. [provided byRefSeq].
Antonicka, H., et al. Am. J. Hum. Genet. 87(1):115-122(2010)Nozaki, Y., et al. Genes Cells 13(5):429-438(2008)Soleimanpour-Lichaei, H.R., et al. Mol. Cell 27(5):745-757(2007)Hansen, L.L., et al. Cytogenet. Cell Genet. 88 (1-2), 91-92 (2000) :Zhang, Y., et al. Biochim. Biophys. Acta 1443 (1-2), 245-250 (1998) :
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