|Other Names||Kinetochore protein Spc25, hSpc25, SPC25, SPBC25|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that may be involved inkinetochore-microtubule interaction and spindle checkpointactivity.
Pare, G., et al. PLoS Genet. 4 (12), E1000312 (2008) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Ciferri, C., et al. J. Biol. Chem. 280(32):29088-29095(2005)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Bharadwaj, R., et al. J. Biol. Chem. 279(13):13076-13085(2004)
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