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SPC25 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9HBM1
Clone Names 110726229
Peptide ID 110726229
Additional Information
Gene ID 57405
Other Names Kinetochore protein Spc25, hSpc25, SPC25, SPBC25
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPC25
Synonyms SPBC25
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
Research Areas
Citations (0)

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Background

This gene encodes a protein that may be involved inkinetochore-microtubule interaction and spindle checkpointactivity.

References

Pare, G., et al. PLoS Genet. 4 (12), E1000312 (2008) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Ciferri, C., et al. J. Biol. Chem. 280(32):29088-29095(2005)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Bharadwaj, R., et al. J. Biol. Chem. 279(13):13076-13085(2004)

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$ 80.00
Cat# BP17479c
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