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RTN2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
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- BACKGROUND
| Primary Accession | O75298 |
|---|---|
| Clone Names | 110617019 |
| Gene ID | 6253 |
|---|---|
| Other Names | Reticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI, RTN2, NSPL1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RTN2 |
|---|---|
| Synonyms | NSPL1 |
| Function | Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (PubMed:15286784). Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q6WN19}; Multi-pass membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70622}; Multi-pass membrane protein. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O70622}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70622}. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes {ECO:0000250|UniProtKB:O70622} |
| Tissue Location | [Isoform RTN2-C]: Highly expressed in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the family of reticulon encodinggenes. Reticulons are associated with the endoplasmic reticulum,and are involved in neuroendocrine secretion or in membranetrafficking in neuroendocrine cells. Alternatively splicedtranscript variants encoding different isoforms have beenidentified.
References
Ikemoto, T., et al. Diabetes 58(12):2802-2812(2009)Liu, Y., et al. J. Biol. Chem. 283(10):6561-6571(2008)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)He, W., et al. Nat. Med. 10(9):959-965(2004)
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