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CBR4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N4T8 |
|---|---|
| Clone Names | 110808094 |
| Gene ID | 84869 |
|---|---|
| Other Names | Carbonyl reductase family member 4, 1---, 3-oxoacyl-[acyl-carrier-protein] reductase, 111-, Quinone reductase CBR4, CBR4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CBR4 |
|---|---|
| Synonyms | SDR45C1 |
| Function | Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)- hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Detected in liver and kidney (at protein level) (PubMed:19000905). Displays the highest expression in neuronal and muscle tissues (PubMed:25203508). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
References
Chen, Z., et al. FASEB J. 23(11):3682-3691(2009)Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Endo, S., et al. Biochem. Biophys. Res. Commun. 377(4):1326-1330(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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