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RNF112 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9ULX5
Clone Names 100603294
Peptide ID 100603294
Additional Information
Gene ID 7732
Other Names RING finger protein 112, Brain finger protein, Zinc finger protein 179, RNF112, BFP, ZNF179
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF112
Synonyms BFP, ZNF179
Function E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell- cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, Nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas {ECO:0000250|UniProtKB:Q96DY5}
Tissue Location Predominantly expressed in brain (PubMed:10574464). Decreased expression in glioma brain tumors as compared to normal brains (at protein level) (PubMed:28684796)
Research Areas
Citations (0)

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Background

This gene encodes a member of the RING finger proteinfamily of transcription factors. The protein is primarily expressedin brain. The gene is located within the Smith-Magenis syndromeregion on chromosome 17.

References

Seki, N., et al. DNA Res. 6(5):353-356(1999)Orimo, A., et al. Genomics 54(1):59-69(1998)Kimura, T., et al. Am. J. Med. Genet. 69(3):320-324(1997)Matsuda, Y., et al. Genomics 33(2):325-327(1996)

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$ 80.00
Cat# BP17554a
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