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AGTPBP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UPW5 |
|---|---|
| Clone Names | 100406208 |
| Gene ID | 23287 |
|---|---|
| Other Names | Cytosolic carboxypeptidase 1, 3417-, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, AGTPBP1, CCP1, KIAA1035, NNA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AGTPBP1 (HGNC:17258) |
|---|---|
| Function | Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed:22170066, PubMed:24022482, PubMed:30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin (PubMed:22170066, PubMed:24022482, PubMed:30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed:24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed:22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed:29593216). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
NNA1 is a zinc carboxypeptidase that contains nuclearlocalization signals and an ATP/GTP-binding motif that wasinitially cloned from regenerating spinal cord neurons of themouse.
References
Lim, J., et al. Cell 125(4):801-814(2006)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Fernandez-Gonzalez, A., et al. Science 295(5561):1904-1906(2002)Harris, A., et al. Mol. Cell. Neurosci. 16(5):578-596(2000)
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