|Other Names||Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, LAMTOR3, MAP2K1IP1, MAPKSP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|
|Cellular Location||Late endosome membrane; Peripheral membrane protein; Cytoplasmic side|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a scaffold protein that functions in theextracellular signal-regulated kinase (ERK) cascade. The protein islocalized to late endosomes by the mitogen-activatedprotein-binding protein-interacting protein, and binds specificallyto MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAPkinase MAPK1/ERK2. Studies of the orthologous gene in mouseindicate that it regulates late endosomal traffic and cellproliferation. Multiple transcript variants are expressed by thisgene, but only one variant is thought to express a protein.
Sancak, Y., et al. Cell 141(2):290-303(2010)Vomastek, T., et al. Mol. Cell. Biol. 27(23):8296-8305(2007)Brahma, A., et al. Arch. Biochem. Biophys. 460(1):85-91(2007)Teis, D., et al. J. Cell Biol. 175(6):861-868(2006)Villegas, S.N., et al. Brain Res. Bull. 71 (1-3), 116-126 (2006) :
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.