|Other Names||Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, LAMTOR3, MAP2K1IP1, MAPKSP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|
|Cellular Location||Late endosome membrane; Peripheral membrane protein; Cytoplasmic side|
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This gene encodes a scaffold protein that functions in theextracellular signal-regulated kinase (ERK) cascade. The protein islocalized to late endosomes by the mitogen-activatedprotein-binding protein-interacting protein, and binds specificallyto MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAPkinase MAPK1/ERK2. Studies of the orthologous gene in mouseindicate that it regulates late endosomal traffic and cellproliferation. Multiple transcript variants are expressed by thisgene, but only one variant is thought to express a protein.
Sancak, Y., et al. Cell 141(2):290-303(2010)Vomastek, T., et al. Mol. Cell. Biol. 27(23):8296-8305(2007)Brahma, A., et al. Arch. Biochem. Biophys. 460(1):85-91(2007)Teis, D., et al. J. Cell Biol. 175(6):861-868(2006)Villegas, S.N., et al. Brain Res. Bull. 71 (1-3), 116-126 (2006) :
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