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MAPKSP1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UHA4
Clone Names 100623270
Peptide ID 100623270
Additional Information
Gene ID 8649
Other Names Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, LAMTOR3, MAP2K1IP1, MAPKSP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAP2K1IP1, MAPKSP1
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Cellular Location Late endosome membrane; Peripheral membrane protein; Cytoplasmic side
Research Areas
Citations (0)

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This gene encodes a scaffold protein that functions in theextracellular signal-regulated kinase (ERK) cascade. The protein islocalized to late endosomes by the mitogen-activatedprotein-binding protein-interacting protein, and binds specificallyto MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAPkinase MAPK1/ERK2. Studies of the orthologous gene in mouseindicate that it regulates late endosomal traffic and cellproliferation. Multiple transcript variants are expressed by thisgene, but only one variant is thought to express a protein.


Sancak, Y., et al. Cell 141(2):290-303(2010)Vomastek, T., et al. Mol. Cell. Biol. 27(23):8296-8305(2007)Brahma, A., et al. Arch. Biochem. Biophys. 460(1):85-91(2007)Teis, D., et al. J. Cell Biol. 175(6):861-868(2006)Villegas, S.N., et al. Brain Res. Bull. 71 (1-3), 116-126 (2006) :

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$ 80.00
Cat# BP17561a
Availability: In Stock
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