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MAPKSP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHA4 |
|---|---|
| Clone Names | 100623270 |
| Gene ID | 8649 |
|---|---|
| Other Names | Ragulator complex protein LAMTOR3, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1, LAMTOR3, MAP2K1IP1, MAPKSP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LAMTOR3 (HGNC:15606) |
|---|---|
| Synonyms | MAP2K1IP1, MAPKSP1 |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:30181260, PubMed:29107538, PubMed:29123114, PubMed:29158492, PubMed:28935770). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). |
| Cellular Location | Late endosome membrane {ECO:0000250|UniProtKB:O88653}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88653}; Cytoplasmic side {ECO:0000250|UniProtKB:O88653}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000250|UniProtKB:O88653} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a scaffold protein that functions in theextracellular signal-regulated kinase (ERK) cascade. The protein islocalized to late endosomes by the mitogen-activatedprotein-binding protein-interacting protein, and binds specificallyto MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAPkinase MAPK1/ERK2. Studies of the orthologous gene in mouseindicate that it regulates late endosomal traffic and cellproliferation. Multiple transcript variants are expressed by thisgene, but only one variant is thought to express a protein.
References
Sancak, Y., et al. Cell 141(2):290-303(2010)Vomastek, T., et al. Mol. Cell. Biol. 27(23):8296-8305(2007)Brahma, A., et al. Arch. Biochem. Biophys. 460(1):85-91(2007)Teis, D., et al. J. Cell Biol. 175(6):861-868(2006)Villegas, S.N., et al. Brain Res. Bull. 71 (1-3), 116-126 (2006) :
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