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NOSIP Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y314 |
|---|---|
| Clone Names | 110717129 |
| Gene ID | 51070 |
|---|---|
| Other Names | Nitric oxide synthase-interacting protein, eNOS-interacting protein, NOSIP |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NOSIP |
|---|---|
| Function | E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813) |
| Tissue Location | Expressed in heart, brain and lung. Present in endothelial cells (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NOSIP negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
References
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Schleicher, M., et al. Mol. Cell. Biol. 25(18):8251-8258(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Dreyer, J., et al. J. Neurosci. 24(46):10454-10465(2004)
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