|Other Names||Nitric oxide synthase-interacting protein, eNOS-interacting protein, NOSIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (PubMed:11149895, PubMed:15548660, PubMed:16135813).|
|Cellular Location||Cytoplasm. Nucleus Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813)|
|Tissue Location||Expressed in heart, brain and lung. Present in endothelial cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
NOSIP negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Schleicher, M., et al. Mol. Cell. Biol. 25(18):8251-8258(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005)Dreyer, J., et al. J. Neurosci. 24(46):10454-10465(2004)
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