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TTDN1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TAP9 |
|---|---|
| Clone Names | 110717210 |
| Gene ID | 136647 |
|---|---|
| Other Names | M-phase-specific PLK1-interacting protein, TTD non-photosensitive 1 protein, MPLKIP, C7orf11, TTDN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MPLKIP |
|---|---|
| Synonyms | C7orf11, TTDN1 |
| Function | May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. |
| Cellular Location | Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase |
| Tissue Location | Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene localizes to thecentrosome during mitosis and to the midbody during cytokinesis.The protein is phosphorylated by cyclin-dependent kinase 1 duringmitosis and subsequently interacts with polo-like kinase 1. Theprotein is thought to function in regulating mitosis andcytokinesis. Mutations in this gene result in nonphotosensitivetrichothiodystrophy.
References
Zhang, Y., et al. Cell. Mol. Life Sci. 64(5):632-640(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Botta, E., et al. Hum. Mutat. 28(1):92-96(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Nakabayashi, K., et al. Am. J. Hum. Genet. 76(3):510-516(2005)
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