|Other Names||M-phase-specific PLK1-interacting protein, TTD non-photosensitive 1 protein, MPLKIP, C7orf11, TTDN1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase|
|Tissue Location||Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles.|
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The protein encoded by this gene localizes to thecentrosome during mitosis and to the midbody during cytokinesis.The protein is phosphorylated by cyclin-dependent kinase 1 duringmitosis and subsequently interacts with polo-like kinase 1. Theprotein is thought to function in regulating mitosis andcytokinesis. Mutations in this gene result in nonphotosensitivetrichothiodystrophy.
Zhang, Y., et al. Cell. Mol. Life Sci. 64(5):632-640(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Botta, E., et al. Hum. Mutat. 28(1):92-96(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Nakabayashi, K., et al. Am. J. Hum. Genet. 76(3):510-516(2005)
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