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RNF219 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5W0B1 |
|---|---|
| Clone Names | 110726200 |
| Gene ID | 79596 |
|---|---|
| Other Names | RING finger protein 219, RNF219, C13orf7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OBI1 (HGNC:20308) |
|---|---|
| Synonyms | C13orf7, RNF219 |
| Function | E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578). |
| Cellular Location | Chromosome. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase |
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Provided below are standard protocols that you may find useful for product applications.
Background
C13orf7 is phosphorylated upon DNA damage, probably by ATM or ATR. However, the function of C13orf7 remains unknown.
References
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Dunham, A., et al. Nature 428(6982):522-528(2004)
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