|Other Names||Tropomodulin-4, Skeletal muscle tropomodulin, Sk-Tmod, TMOD4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.|
|Cellular Location||Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).|
|Tissue Location||Highly expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
TMOD4 blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
Lamesch, P., et al. Genomics 89(3):307-315(2007)Cox, P.R., et al. BMC Genomics 2 (1), 7 (2001) :Cox, P.R., et al. Genomics 63(1):97-107(2000)Almenar-Queralt, A., et al. J. Biol. Chem. 274(40):28466-28475(1999)
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