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MYH7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12883 |
|---|---|
| Clone Names | 110729012 |
| Gene ID | 4625 |
|---|---|
| Other Names | Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MYH7 |
|---|---|
| Synonyms | MYHCB |
| Function | Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. |
| Cellular Location | Cytoplasm, myofibril {ECO:0000250|UniProtKB:P02564}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P02564}. Note=Thick filaments of the myofibrils {ECO:0000250|UniProtKB:P02564} |
| Tissue Location | Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Muscle myosin is a hexameric protein containing 2 heavychain subunits, 2 alkali light chain subunits, and 2 regulatorylight chain subunits. This gene encodes the beta (or slow) heavychain subunit of cardiac myosin. It is expressed predominantly innormal human ventricle. It is also expressed in skeletal muscletissues rich in slow-twitch type I muscle fibers. Changes in therelative abundance of this protein and the alpha (or fast) heavysubunit of cardiac myosin correlate with the contractile velocityof cardiac muscle. Its expression is also altered during thyroidhormone depletion and hemodynamic overloading. Mutations in thisgene are associated with familial hypertrophic cardiomyopathy,myosin storage myopathy, dilated cardiomyopathy, and Laingearly-onset distal myopathy.
References
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)Muelas, N., et al. Neurology 75(8):732-741(2010)Zheng, D.D., et al. J. Int. Med. Res. 38(3):810-820(2010)
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