|Other Names||Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, myofibril. Note=Thick filaments of the myofibrils|
|Tissue Location||Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level)|
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Muscle myosin is a hexameric protein containing 2 heavychain subunits, 2 alkali light chain subunits, and 2 regulatorylight chain subunits. This gene encodes the beta (or slow) heavychain subunit of cardiac myosin. It is expressed predominantly innormal human ventricle. It is also expressed in skeletal muscletissues rich in slow-twitch type I muscle fibers. Changes in therelative abundance of this protein and the alpha (or fast) heavysubunit of cardiac myosin correlate with the contractile velocityof cardiac muscle. Its expression is also altered during thyroidhormone depletion and hemodynamic overloading. Mutations in thisgene are associated with familial hypertrophic cardiomyopathy,myosin storage myopathy, dilated cardiomyopathy, and Laingearly-onset distal myopathy.
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)Millat, G., et al. Eur J Med Genet 53(5):261-267(2010)Muelas, N., et al. Neurology 75(8):732-741(2010)Zheng, D.D., et al. J. Int. Med. Res. 38(3):810-820(2010)
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