|Other Names||Butyrophilin subfamily 3 member A3, BTN3A3, BTF3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in T-cell responses in the adaptive immune response.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The butyrophilin (BTN) genes are a group of majorhistocompatibility complex (MHC)-associated genes that encode typeI membrane proteins with 2 extracellular immunoglobulin (Ig)domains and an intracellular B30.2 (PRYSPRY) domain. Threesubfamilies of human BTN genes are located in the MHC class Iregion: the single-copy BTN1A1 gene (MIM 601610) and the BTN2(e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, whichhave undergone tandem duplication, resulting in 3 copies of each(summary by Smith et al., 2010 [PubMed 20208008]).[supplied byOMIM].
Smith, I.A., et al. J. Immunol. 184(7):3514-3525(2010)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Rhodes, D.A., et al. Genomics 71(3):351-362(2001)Henry, J., et al. Immunol. Today 20(6):285-288(1999)Ruddy, D.A., et al. Genome Res. 7(5):441-456(1997)
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